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By: MyCocktailRecipes.com Team
Updated on: 4/24/2025
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Unveiling the Penicillin Cocktail: A Smoky Delight with a Twist

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There’s something utterly captivating about sipping a drink that combines the warmth of whiskey with the zing of ginger and the sweetness of honey. The Penicillin cocktail, a modern classic, does just that, and it's been winning hearts since its creation. Picture this: a chilly evening in New York, the dim glow of bar lights, and a drink that feels like a warm hug in a glass. That’s the magic of this concoction, and today, I’m thrilled to share everything you need to know to make it your own.

Quick Facts

  • Difficulty: Moderate
  • Prep Time: 10 minutes
  • Servings: 1
  • Alcohol Content: Approximately 25-30% ABV
  • Calories: Around 220 per serving

The Story Behind the Penicillin Cocktail

The Penicillin cocktail was born in the bustling city of New York, crafted by the talented Sam Ross at the famous Milk & Honey bar. This drink is a tribute to the classic hot toddy, but with a refreshing twist that makes it stand out. Ross combined smoky whiskey with honey-ginger syrup to create a drink that not only warms the soul but also tantalizes the taste buds. It’s like having a taste of history in every sip!

Ingredients and Their Unique Charm

To make this delightful mix, you'll need:
  • 60 ml of blended Scotch whisky: The backbone of the drink, providing a smooth and robust flavor.
  • 7.5 ml of smoky Islay Scotch: Adds a smoky depth that elevates the entire experience.
  • 22.5 ml of fresh lemon juice: Brings a refreshing citrusy balance.
  • 22.5 ml of honey-ginger syrup: The sweet and spicy heart of the cocktail.

Classic Penicillin Cocktail Recipe

Ready to try your hand at crafting this iconic drink? Here’s how you do it:
  • Combine the blended Scotch, lemon juice, and honey-ginger syrup in a shaker filled with ice.
  • Shake vigorously until well chilled.
  • Strain the mix into a rocks glass filled with ice.
  • Float the smoky Islay Scotch over the top by pouring it over the back of a spoon.
  • Garnish with a slice of fresh ginger or a lemon twist.

Variations and Adaptations

While the classic version is a favorite, there are a few variations you might want to explore:
  • Mexican Penicillin: Swap the Scotch for mezcal for a smoky, earthy twist.
  • Honey-Lemon Penicillin: Use honey liqueur instead of honey-ginger syrup for a sweeter touch.
  • Herbal Penicillin: Add a splash of herbal liqueur for a complex, aromatic profile.

Tips for the Perfect Serve

To truly enjoy this cocktail, consider these serving tips:
  • Glassware: A rocks glass is ideal for showcasing the drink’s beautiful layers.
  • Ice: Use large ice cubes to keep the drink chilled without diluting it too quickly.
  • Garnish: A slice of candied ginger or a sprig of rosemary can add a delightful aroma.

Share Your Penicillin Experience!

Try making this smoky delight at home and let us know how it goes! Share your thoughts and any personal twists you’ve added in the comments below. And don’t forget to spread the joy by sharing this recipe with your friends on social media. Cheers to crafting and enjoying the perfect Penicillin cocktail!

FAQ Penicillin

How can I make a Penicillin cocktail with a twist?
To give the Penicillin cocktail a twist, try adding a splash of ginger beer for effervescence or infusing the honey syrup with herbs like rosemary for an aromatic touch.
How does the Penicillin cocktail compare to other whisky cocktails?
The Penicillin cocktail is often compared to other whisky cocktails like the Whisky Sour or the Rusty Nail. Its unique combination of smoky and sweet flavors sets it apart, making it a favorite among whisky enthusiasts.
Can the Penicillin cocktail be made non-alcoholic?
While the Penicillin cocktail is traditionally alcoholic, a non-alcoholic version can be made by substituting the whisky with a smoky tea or a non-alcoholic whisky alternative, maintaining the honey-ginger syrup and lemon juice for flavor.
What is the history behind the name 'Penicillin' for this cocktail?
The name 'Penicillin' for this cocktail is a playful nod to the medicinal properties of ginger and honey, which are known for their soothing effects, much like the antibiotic penicillin.
Is the Penicillin cocktail popular worldwide?
The Penicillin cocktail has gained international popularity since its creation, becoming a staple on cocktail menus worldwide due to its unique flavor profile and the growing interest in craft cocktails.
What is the best way to serve a Penicillin cocktail?
The best way to serve a Penicillin cocktail is in a rocks glass over a large ice cube, garnished with a slice of candied ginger or a lemon twist to enhance its aromatic qualities.
What type of glass is ideal for a Penicillin cocktail?
A Penicillin cocktail is typically served in a rocks glass, which allows for the optimal enjoyment of its complex flavors and aromas.
Can I use a different type of whisky in a Penicillin cocktail?
While the traditional Penicillin cocktail uses Scotch whisky, you can experiment with other types of whisky, such as bourbon or rye, to create a different flavor profile.
Is the Penicillin cocktail considered a classic drink?
Yes, the Penicillin cocktail is considered a modern classic, recognized for its innovative use of ingredients and its balanced, complex flavor.
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